US EPA

4115198 

Journal Article 

Stability of ondansetron hydrochloride and dexamethasone sodium phosphate in 0.9% sodium chloride injection and in 5% dextrose injection 

Evrard, B; Ceccato, A; Gaspard, O; Delattre, L; Delporte, JP 

1997 

Yes 

American Journal of Health-System Pharmacy
ISSN: 1079-2082
EISSN: 1535-2900 

IPA/97/1127286 

54 

9 

1065-1068 

English 

WOS:A1997WY42700015 

IPA COPYRIGHT: ASHP A study evaluating the compatibility of various concentrations of ondansetron hydrochloride (Zofran) and dexamethasone sodium phosphate (Decadron Phosphate) in 0.9% sodium chloride or 5% dextrose injections stored in polyvinyl chloride (PVC) bags under refrigeration or at room temperature for up to 28 days is reported; dexamethasone injections were prepared from injections with initial concentrations of 3.3 and 20 mg/ml. Visual examinations of each admixture at each sampling time did not reveal any evidence of turbidity or color change. The pH of the admixtures changed by and lt;=0.2 pH unit during the study. The pH of admixtures prepared with 3.3 mg/ml injections of dexamethasone was 0.2-0.5 pH unit greater than that of the comparable admixtures prepared with 20 mg/ml injections of dexamethasone. Whatever the storage conditions, dexamethasone remained stable; under several study conditions, the concentration of ondansetron remaining was and lt;95% of the initial concentration. The chromatograms did not reveal peaks representing the 2 products of ondansetron degradation.