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4115312 
Journal Article 
Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note 
Bhumkar, DR; Pokharkar, VB 
2006 
Yes 
AAPS PharmSciTech
ISSN: 1530-9932 
7 
2 
E50 
English 
16796367 
WOS:000238975900019 
The ionotropic gelation method for formation of crosslinked chitosan particles can be easily modified from ionic cross-linking to deprotonation by adjusting the pH of TPP. Chitosan was cross-linked ionically with TPP at lower pH and by deprotonation mechanism at higher pH. The swelling behavior of cross-linked chitosan appeared to depend on the pH of TPP. The ionically cross-linked chitosan showed higher swelling ability. Thus the nature of crosslinked chitosan can be tailor made to obtain the desired properties in terms of cross-linking density, crystallinity, and hydrophilicity. 
chitosan; deprotonation; ionic cross-linking; mechanistic study; tripolyphosphate