Dipalma, JA; Buckley, SE; Warner, BA; Culpepper, RM
Sodium phosphate catharsis has been shown to be effective and well tolerated for colon cleansing. The little available data concerning laboratory effects indicate hyperphosphatemia and hypocalcemia with this preparation. This investigation was designed to monitor serum and urine biochemical changes after oral sodium phosphate (OSP) cleansing. Seven healthy, asymptomatic adults comprised the study group (4 women and 3 men, mean age 32.9 _+3.5SEM). Enrollment screening CBC, BUN, creatinine and electrolytes were normal. OSP 45cc diluted in water was given at baseline and 12h later. Calcium (Ca), Ionized Calcium (Ca0, Phosphorus (P), Sodium (Na), Potassium (K), Creatinine (Cre) and PTH were analyzed at 2, 4, 6, 9, 12, 14, 16, 18, 21 and 24h after the first OSP challenge. Urinary Ca, P, Na, K, Cre and cAMP were analyzed at baseline and every 2h after OSP. Blood pressure, pulse and respiratory rate were recorded every 2h and symptom questionnaires were completed.