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HERO ID
4117789
Reference Type
Journal Article
Subtype
Review
Title
PLGA-based nanoparticles: an overview of biomedical applications
Author(s)
Danhier, F; Ansorena, E; Silva, JM; Coco, R; Le Breton, A; Préat, V
Year
2012
Is Peer Reviewed?
Yes
Journal
Journal of Controlled Release
ISSN:
0168-3659
EISSN:
1873-4995
Volume
161
Issue
2
Page Numbers
505-522
Language
English
PMID
22353619
DOI
10.1016/j.jconrel.2012.01.043
Web of Science Id
WOS:000305790300035
Abstract
Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers. Among the different polymers developed to formulate polymeric nanoparticles, PLGA has attracted considerable attention due to its attractive properties: (i) biodegradability and biocompatibility, (ii) FDA and European Medicine Agency approval in drug delivery systems for parenteral administration, (iii) well described formulations and methods of production adapted to various types of drugs e.g. hydrophilic or hydrophobic small molecules or macromolecules, (iv) protection of drug from degradation, (v) possibility of sustained release, (vi) possibility to modify surface properties to provide stealthness and/or better interaction with biological materials and (vii) possibility to target nanoparticles to specific organs or cells. This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases. This review focuses on the understanding of specific characteristics exploited by PLGA-based nanoparticles to target a specific organ or tissue or specific cells.
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