Shils's solution interaction with potassium phosphate, sodium phosphate and calcium gluceptate in 8% amino acid solution | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

4120475

Reference Type

Journal Article

Subtype

Letter

Title

Shils's solution interaction with potassium phosphate, sodium phosphate and calcium gluceptate in 8% amino acid solution

Author(s)

Garfield, PF

Year

1978

Is Peer Reviewed?

Yes

Journal

American Journal of Hospital Pharmacy
ISSN: 0002-9289

Report Number

IPA/79/324128

Volume

Issue

REF

Page Numbers

1190

Language

English

PMID

100006

Abstract

IPA COPYRIGHT: ASHP Reported are 2 reactions in total parenteral nutrient solutions involving trace minerals. When Shils's formula, a solution containing anhydrous citric acid; cupric sulfate5H20; manganese sulfateH20; sodium iodide; zinc chloride; and water for injection is added to either potassium or sodium phosphate, without mixing, copper is precipitated, presumably as CuHPO4. Copper remains in the cupric form. When Shils's formula is added to calcium gluceptate, without mixing, the resultant solution obtains a yellow tinge, and the characteristic odor of iodine is noted. Clinical significance of the above reactions is not known. However, if the solutions are well mixed between additions, the reactions are not seen.