Ocular bioavailability of topical prednisolone preparations | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4120655

Reference Type

Journal Article

Title

Ocular bioavailability of topical prednisolone preparations

Author(s)

Olejnik, O; Weisbecker, CA

Year

1990

Is Peer Reviewed?

Yes

Journal

Clinical Therapeutics
ISSN: 0149-2918

Report Number

IPA/90/918176

Volume

Ther

Issue

REF 27

Page Numbers

2-11

Language

English

Abstract

IPA COPYRIGHT: ASHP Research on the anti-inflammatory effects of prednisolone sodium phosphate (I) ophthalmic solution and prednisolone acetate (II) ophthalmic suspension is reviewed critically and methodological problems in the study of ocular drugs are identified. A pharmacokinetic model of the absorption of water-insoluble drugs (such as II) and water-soluble drugs (such as I) including drug elimination and dissolution, rates of drug penetration and transport is presented; both drugs have moderate to high anti-inflammatory effects. It is concluded that even though anti-inflammatory effects are similar, a solution of I is preferable to a suspension of II due to the possibilities of poor particle distribution leading to incorrect dosing.