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4120700 
Journal Article 
Compatibility and stability of granisetron, dexamethasone, and methylprednisolone in injectable solutions 
Pinguet, F; Rouanet, P; Martel, P; Fabbro, M; Astre, C; Et al 
1995 
Yes 
Journal of Pharmaceutical Sciences
ISSN: 0022-3549
EISSN: 1520-6017 
IPA/96/1089217 
Pharm 
REF 14 
267-268 
English 
IPA COPYRIGHT: ASHP The stability of injection solutions containing granisetron hydrochloride alone or with dexamethasone sodium phosphate or methylprednisolone hemisuccinate was studied under various conditions. At each sampling time, all admixtures were clear and without any change of color. The pH of the samples did not vary over the study period. No influence of light was seen on granisetron stability. Granisetron was stable at concentrations of 0.056 and 0.15 mg/ml in solutions of 5% dextrose and 0.9% sodium chloride at -20DGC, 4DGC, and ambient temperatures and in different containers. Granisetron was also stable when mixed with different concentrations of dexamethasone or methylprednisolone. It was concluded that granisetron solutions are stable and can be stored under various conditions, even in the presence of methylprednisolone or dexamethasone.