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4121096 
Journal Article 
Preformulation characterization of topical ibuprofen piconol 
Pesheck, CV; Osborne, DW 
1993 
Yes 
Drug Development and Industrial Pharmacy
ISSN: 0363-9045
EISSN: 1520-5762 
IPA/94/1054211 
Ind 
REF 12 
1889-1902 
English 
IPA COPYRIGHT: ASHP The preformulation characteristics of ibuprofen piconol, a nonsteroidal anti-inflammatory agent used for the topical relief of primary thermal burns and sunburns, are reported, including melting properties, specific gravity, viscosity, hygroscopicity, moisture content, acid-base properties, surface tension, solubility, and partitioning. Chemical stability results are given for the bulk drug, the drug in solution, and the drug after formulation in both a cream and an ointment. These preformulation characteristics indicate that ibuprofen piconol is a chemically stable, slightly hygroscopic liquid that strongly partitions into the oil phase and shows no indication of surface activity. Ibuprofen piconol degrades in the presence of metal ions. The ibuprofen cream and ointment are both stable to chemical degradation and to physical separation. After 6 months, the cream showed insignificant degradation, and the ointment showed less than 3% degradation.