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4141098 
Journal Article 
Microwave assisted synthesis of indole and furan derivatives possessing good anti-inflammatory and analgesic activity 
Sondhi, SM; Jain, S; Rani, R; Kumar, A 
2007 
1 
Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983 
46 
11 
1848-1854 
English 
WOS:000251378600003 
Indole-2-carboxylic acid on condensation with benzene Sulfonyl hydrazide and p-toluene sulfonyl hydrazide gives condensation products 1a and 1b. 1H-Tetrazole-5-acetic acid, hydantoin-5-acetic acid, orotic acid, 5-bromo nicotinic acid and indole 2-carboxylic acid have been condensed with I'Lirfuryl ainine to give con-csponding condensation pioducts, la-e whereas condensation or succinic acid and adipic acid with furfuryl amine gives products 3a and 3b respectively. 3.5-Pyrazole dicarboxlic acid. 4,5-imidazole dicarboxylic acid and 3-carnboxy-1,4-dimethyl pyrole-2-acetic acid on condensation with furfuryl amine give compounds 4, 5 and 6. All these compounds i.e. 1a,b, 2a-e, 3a,b, 4, 5 and 6 have been characterized by spectroscopic means and have been screened For anti-inflammatory and analgesic activity. Compounds 2a. and 5 exhibit good anti-inflammatory and 2a, 2c and 5 exhibit good analgesic activity. 
microwave; indole; furan; anti-inflammatory,analgesic