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HERO ID
4141733
Reference Type
Journal Article
Title
Urinary S-phenylmercapturic acid as a key biomarker for measuring occupational exposure to low concentrations of benzene in Chinese workers: A pilot study
Author(s)
Lv, BH; Song, SZ; Zhang, Z; Mei, Y; Ye, FL
Year
2014
Is Peer Reviewed?
Yes
Journal
Journal of Occupational and Environmental Medicine
ISSN:
1076-2752
EISSN:
1536-5948
Volume
56
Issue
3
Page Numbers
319-325
Language
English
PMID
24561506
DOI
10.1097/JOM.0000000000000098
Web of Science Id
WOS:000335900200014
Relationship(s)
has erratum
4143131
(vol 56, pg 319, 2014)
Abstract
OBJECTIVE:
This study analyzed the level of urinary S-phenylmercapturic acid (U-SPMA) for low benzene exposure in a group of Chinese shoe-making workers.
METHODS:
Urinary samples from 55 workers exposed to benzene at levels lower than 10 parts per million (ppm) were collected at postshift. U-SPMA level was determined using high-performance liquid chromatography/mass spectrography (HPLC/MS) method.
RESULTS:
Good linearity of U-SPMA was observed within the range from 10 to 320 μg/L (r = 0.9994). Concentration of airborne benzene ranged from 0.71 to 32.17 mg/m³, and three segments were divided with different levels of exposure (≤6.0, 6.0 to 10.0, 10 to 32.5 mg/m³), the median U-SPMA concentrations were 49.55, 102.15, and 335.69 μg/g Cr, respectively.
CONCLUSION:
A good linear correlation was found between U-SPMA levels and airborne benzene concentrations. The selected method could be applied for detecting other working conditions in China.
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