US EPA

4142808 

Journal Article 

Synthesis and Biological Evaluation of Thiazolidin-4-ones 

Rajeeva, B; Kumar, AP; Shantakumar, SM 

2009 

Yes 

Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 

21 

9 

6951-6956 

English 

WOS:000271301600050 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955209006&partnerID=40&md5=398922421cfc4163db0c0b28e0c6646e
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A new series of 2-(1,3-benzothiazol-2-ylimino)-5-arylidene-1,3-thiazolidine-4-ones (4) were synthesized and evaluated for their antiinflammatory and analgesic activity. The 2-(1,3-benzothiazol-2-ylimino)-5-arylidene-1,3-thiazolidine-4-one (4) were synthesized from 2-(1,3-benzothiazol-2-ylimino)-1,3-thiazolidin-4-one (3) upon treating with different substituted aryl aldehydes. The 2-(1,3-benzothiazol-2-ylimino)1,3-thiazolidin-4-one (3) was prepared by treating 2-chloroacetamido benzothiazole (2) with potassium thiocyanate, where as the compound 2 was prepared by treating 2-aminobenzothiazole with chloroacetyl chloride in benzene medium. The synthesized 2-(1,3-benzothiazol-2-ylimino)-5-aryl-1,3-thiazolidine-4-one (4a(1)-a(10)) were screened for antiinflammatory and analgesic activity. The tested compounds exhibited good anti inflammatory and analgesic activity as compared to standard drug. 

Synthesis; Benzothiazole; Chloroacetyl chloride; Thiazolidinone; Antiinflammatory and Analgesic activity