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4158411 
Journal Article 
Summaries of toxicological data III. Chronic oral toxity studies of sodium trimetaphosphate in rats 
Hodge, HC 
1964 
1 
Food and Cosmetics Toxicology
ISSN: 0015-6264
EISSN: 1878-6049 
2 
150-151 
English 
is part of a larger document 1326436 Toxicity studies on phosphates
Rats. The acute LDso of sodium trimetaphosphate (TMP) when given intraperitoneally to female rats was 3650 +/- 620 mg/kg. Groups of 5 male rats were maintained for 1 month on diets composed of Fox Chow meal with the following additions: group I, controls--basal ration only; group II, controls--10 % sodium chloride; group III, controls--5 % disodium phosphate; groups IV (a,b,c), 0.2, 2.0 and 10 % respectively of TMP.

Growth of rats in groups I, III, IV(a) and IV(b) was comparable but was retarded in rats of groups II and IV(c). Rats in group IV(c) displayed slightly increased kidney weights and only slight transient changes in the kidney tubules ('transient' in the sense that they were present at 15 days but not at 28 days). Kidneys of rats in group [I were heavier than no~ real and displayed kidney changes, but of a different sort. Tubular and other pathological effects were seen in the kidneys of rats in group III.

Dogs. One dog fed 0.1 g/kg/day for 1 month maintained normal body weight. Urine analysis, haematological tests and histological examinations of tissues showed no abnormality. Organ weights were normal.

A second dog fed doses increasing from 1-4 g/kg/day for the same period lost 1.4 kg in body weight. Its heart weight lay in the upper limit of the normal range of heart weights. Renal tubular damage was present similar to the phosphate nephritis observed in rats.