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HERO ID
4163650
Reference Type
Journal Article
Subtype
Review
Title
Chelation therapy in intoxications with mercury, lead and copper
Author(s)
Cao, Y; Skaug, MA; Andersen, O; Aaseth, J
Year
2015
Is Peer Reviewed?
1
Journal
Journal of Trace Elements in Medicine and Biology
ISSN:
0946-672X
EISSN:
1878-3252
Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
Location
JENA
Volume
31
Page Numbers
188-192
Language
English
PMID
24894443
DOI
10.1016/j.jtemb.2014.04.010
Web of Science Id
WOS:000356192400030
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929656616&doi=10.1016%2fj.jtemb.2014.04.010&partnerID=40&md5=5a7fca900aa71e0162e48f8405c52cf0
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Abstract
In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the urine. These drugs can be administered orally and have relatively low toxicity compared to the classical antidote dimercaptopropanol (BAL). d-Penicillamine has been widely used in copper overload, although 2,3-dimercaptosuccinic acid or tetrathiomolybdate may be more suitable alternatives today. In copper-toxicity, a free radical scavenger might be recommended as adjuvant to the chelator therapy.
Conference Name
10th Nordic Symposium on Trace Elements in Human Health and Disease
Conference Location
Loen, NORWAY
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