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4163650 
Journal Article 
Review 
Chelation therapy in intoxications with mercury, lead and copper 
Cao, Y; Skaug, MA; Andersen, O; Aaseth, J 
2015 
Journal of Trace Elements in Medicine and Biology
ISSN: 0946-672X
EISSN: 1878-3252 
ELSEVIER GMBH, URBAN & FISCHER VERLAG 
JENA 
31 
188-192 
English 
In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the urine. These drugs can be administered orally and have relatively low toxicity compared to the classical antidote dimercaptopropanol (BAL). d-Penicillamine has been widely used in copper overload, although 2,3-dimercaptosuccinic acid or tetrathiomolybdate may be more suitable alternatives today. In copper-toxicity, a free radical scavenger might be recommended as adjuvant to the chelator therapy. 
10th Nordic Symposium on Trace Elements in Human Health and Disease 
Loen, NORWAY