US EPA

4163650 

Journal Article 

Review 

Chelation therapy in intoxications with mercury, lead and copper 

Cao, Y; Skaug, MA; Andersen, O; Aaseth, J 

2015 

1 

Journal of Trace Elements in Medicine and Biology
ISSN: 0946-672X
EISSN: 1878-3252 

ELSEVIER GMBH, URBAN & FISCHER VERLAG 

JENA 

31 

188-192 

English 

24894443 

10.1016/j.jtemb.2014.04.010 

WOS:000356192400030 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929656616&doi=10.1016%2fj.jtemb.2014.04.010&partnerID=40&md5=5a7fca900aa71e0162e48f8405c52cf0
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In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the urine. These drugs can be administered orally and have relatively low toxicity compared to the classical antidote dimercaptopropanol (BAL). d-Penicillamine has been widely used in copper overload, although 2,3-dimercaptosuccinic acid or tetrathiomolybdate may be more suitable alternatives today. In copper-toxicity, a free radical scavenger might be recommended as adjuvant to the chelator therapy. 

10th Nordic Symposium on Trace Elements in Human Health and Disease 

Loen, NORWAY