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HERO ID
41999
Reference Type
Journal Article
Title
Mutagenicity and cytotoxicity of 2-butoxyethanol and its metabolite, 2-butoxyacetaldehyde, in Chinese hamster ovary (CHO-AS52) cells
Author(s)
Chiewchanwit, T; Au, WW
Year
1995
Is Peer Reviewed?
1
Journal
Mutation Research
ISSN:
0027-5107
EISSN:
1873-135X
Report Number
EMIC/96901
Volume
334
Issue
3
Page Numbers
341-346
Language
English
PMID
7753097
DOI
10.1016/0165-1161(95)90071-3
Web of Science Id
WOS:A1995QW61200008
Abstract
2-Methoxyethanol (2-ME) is being substituted by 2-butoxyethanol (2-BE) as a solvent for the preparation of industrial and consumer products. Since we have shown that a metabolite of 2-methoxyethanol, methoxyacetaldehyde (MALD), is mutagenic in a subline of Chinese hamster ovary cells (CHO-AS52), we have conducted a similar study using 2-BE and its metabolite, butoxyacetaldehyde (BALD). The results indicate that 2-BE and BALD are not mutagenic to CHO-AS52 cells. However, 2-BE is more cytotoxic than 2-ME. In comparison of our study with others on glycol ethers, the data indicate that, for glycol ethers, cytotoxicity increased with chain length of the alkyl groups. For their metabolites, mutagenicity increases with reduced chain length. Therefore, we suggest that safer solvents should be developed for use in preparation of products.
Keywords
2-Methoxyethanol; 2-Butoxyethanol; Methoxyacetaldehyde; 2-Butoxyacetaldehyde; Chinese hamster ovary cells; Cytotoxicity; Gene mutation
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