NTP technical report on toxicity studies of ethylene glycol ethers: 2-Methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol (CAS Nos 109-86-4, 110-80-5, 111-76-2) administered in drinking water to F344/N rats and B6C3F1 mice
National Toxicology Program
Research Triangle Park, NC
NIH Publication 93-3349
Glycol alkyl ethers represent a class of high-production-volume chemicals with widespread industrial applications as solvents and chemical intermediates. Comparative toxicity studies with three glycol ethers, 2-methoxyethanol, 2-ethoxyethanol, and 2-butoxyethanol, were conducted in F344/N rats and B6C3F1 mice in both 2-week and 13-week drinking water studies. Toxicologic endpoints evaluated in animals included histopathology, hematology, clinical chemistry, urinalysis, and reproductive system parameters. Genetic toxicity was also evaluated for each glycol ether in several in vitro and in vivo assays.
Rats Mice Organ weight Body weight Pathology Histology Neoplasms Mutagenicity tests; Ethylene glycols Toxicity Drinking water; 2-methoxyethanol 2-ethoxyethanol 2-butoxyethanol CAS 109-86-4 CAS 110-80-5 CAS 111-76-2