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4225760 
Journal Article 
Synthesis and antimicrobial screening of novel bis-triazolo-dithiadiazines containing bridgehead nitrogen 
Deohate, PP; Kawle, PR 
2015 
Yes 
Journal of the Indian Chemical Society
ISSN: 0019-4522 
92 
6 
911-914 
English 
WOS:000357762800022 
1,4-Bis-(3-arylimino-[1,2,4]-triazolo-[3,4-c]-[1,2,4,5]-dithiadiazin-6-yl)-benzenes have been synthesized by treating 1,4-bis-(4-amino-3-mercapto-4H[1,2,4]-triazol-5-yl-benzene with N-aryl-S-chloro isothiocarbamoyl chlorides and then basification with dilute ammonia solution. Synthesis of 1,4-bis-(4-amino-3-mercapto-4H-[1,2,4]-triazol-5-yl-benzene was carried out by interacting the terephthalic acid dihydrazide with carbondisulphide in presence of potassium hydroxide and then by adding the hydrazine hydrate. Bis-triazolo-dithiadiazines on acetylation afforded di-acetyl derivatives. Structures of title compounds were delineated on the basis of determination of equivalent weight, chemical transformation, elemental analysis and spectral studies. These compounds have been assayed for their antibacterial and antifungal activity against various micro-organisms. 
Novel bis-triazolo-dithiadiazines; synthesis; antimicrobial activity