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4227358 
Journal Article 
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1,2,4-TRIAZOLE DERIVATIVES 
Talawar, MB; Laddi, UV; Somannavar, YS; Bennur, RS; Bennur, SC 
1995 
Yes 
Indian Journal of Heterocyclic Chemistry
ISSN: 0971-1627 
4 
4 
297-300 
WOS:A1995RG09500013 
Reactions of 3-(4-substituted anilinoethyl)-4-amino-5-mercapto-4(H)-1,2,4-triazoles with various aliphatic/aromatic acids, cyanogen bromide, carbon disulphide, hydrazine hydrate, dimedone and monochloroacetic acid are described. Antimicrobial screening of all the synthesised compounds against bacteria Bacillus cirroflagellosus, Escherichia coli and fungi Candida albicans, Aspergillus niger have been carried out. Some of the compounds have shown most significant antifungal activity (Relative inhibition, RI = 60-93%), against both the fungal strains. However most of the compounds have shown moderate antibacterial activity (RI = 30-60%). An attempt is made to study the structure activity relationship (SAR).