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Citation
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HERO ID
4240315
Reference Type
Journal Article
Title
Efficient Synthesis of tert-Butyl (6-Formylpyridin-2-yl)carbamic Acid
Author(s)
Majgier-Baranowska, H; Li, B; Peet, NP
Year
2013
Is Peer Reviewed?
1
Journal
Synthetic Communications
ISSN:
0039-7911
Volume
43
Issue
8
Page Numbers
1173-1180
Language
English
DOI
10.1080/00397911.2011.625291
Web of Science Id
WOS:000322302200010
Abstract
We have developed an efficient four-step synthesis of tert-butyl (6-formylpyridin-2-yl) carbamic acid (1) in 80% overall yield using inexpensive starting material and reagents and no air-sensitive reagents. Column chromatography was not required for purification of the intermediates or the final product.
Keywords
6-Aminopyridine-2-carboxaldehyde; 6-aminopyridine-2-carboxylic acid; bis-Boc protection; building block synthesis; carbamate protection
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