US EPA

4261911 

Journal Article 

Synthesis, Characterization and Biological Activity of the Manganese Complexes with alpha-ketoglutaric Acid and 1-(o-tolyl) Biguanide 

Mihalache, M; Oprea, O; Guran, C; Ardelean, IL 

2017 

1 

Revista de Chimie
ISSN: 0034-7752
EISSN: 2668-8212 

68 

10 

2209-2214 

WOS:000416750000002 

This paper presents the synthesis and characterization of three complexes of Mn (II,III), with the alfa-ketoglutaric acid (H(2)A) and 1-(o-tolyl) biguanide (TB) as ligands. The complexes corresponding formulas are: [Mn (TB)(2)(H(2)A)]Cl-2 center dot 0.5C(2)H(2)OH (C1), [Mn-2 (TB) (A) (H(2)A)(2) (H2O)(2)](NO3)(2)] (NO3)(2) center dot C2H5OH (C2) and [Mn-2 (TB) (A) (H(2)A)(2)(H2O)(2)(CH3COO)(2)](CH3COO)(2) center dot 3H(2)O (C3), where A is H(2)A without 2 protons. C1-C3 compounds were characterized by standard physico-chemical methods: chemical elemental analysis, IR spectroscopy, UV-Vis-NIR spectroscopy, molar conductivity and thermal analysis. For the obtained C1-C3 complexes, but also for the ligands (H(2)A and TB) was tested the antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 and antitumor activity on HeLa tumour cells. It has been observed a moderate cytotoxic effect of the complexes C1-C3 on growth and metabolic activity of HeLa cells, while the ligands show a very weak effect on them. The obtained complexes inhibits the adhesion on the substrate of bacterial strains Staphylococcus aureus and Pseudomona aeruginosa, which recommends them for possible therapeutic applications. 

alpha lambda phi alpha-ketoglutaric acid; 1-(o-tolyl) biguanide; manganese complexes; biological activity