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4266085 
Journal Article 
Review 
Engineering ligninolytic consortium for bioconversion of lignocelluloses to ethanol and chemicals 
Bilal, M; Nawaz, MZ; Iqbal, HMN; Hou, J; Mahboob, S; Al-Ghanim, KA; Hairong, C 
2018 
1 
Protein and Peptide Letters
ISSN: 0929-8665
EISSN: 1875-5305 
25 
2 
108-119 
English 
29359652 
WOS:000431706300003 
Raising environmental concerns and recent global scenario of cleaner production and consumption are leading the world to design green industrial processes to produce alternative fuels and chemicals. Lignocellulosic biomass is enormous and renewable biological resource to produce ethanol and chemicals on sustainable and environmentally basis. Although, bioethanol is one of the most promising and eco-friendly alternatives to fossil fuels yet its production from food and feed has received much negative criticism. Bioethanol production from lignocellulosic biomass can largely satisfy the possible inconsistency of first generation ethanol since it utilizes inedible lignocellulosic feedstocks, primarily sourced from agriculture and forestry wastes. Two major polysaccharides in lignocellulosic biomass namely, cellulose and hemicellulose constitute a complex lignocellulosic network by connecting with lignin which is highly recalcitrant to depolymerization. Several attempts have been made to reduce the cost involved in the process through improving the pretreatment process. While, the ligninolytic enzymes of white rot fungi (WRF) including laccase, lignin peroxidase (LiP), and manganese peroxidase (MnP) have appeared as versatile biocatalysts for delignification of several lignocellulosic residues. The first part of the review mainly focused on engineering ligninolytic consortium. In the second part, WRF and its unique ligninolytic enzyme-based bio-delignification of lignocellulosic biomass, enzymatic hydrolysis, and fermentation of hydrolyzed feedstock are discussed. The metabolic engineering, enzymatic engineering, synthetic biology aspects for ethanol production and platform chemicals production are comprehensively reviewed in the third part. Towards the end information is also given on futuristic viewpoints. 
Biocatalyst; Biofuel; Delignification; Ligninolytic engineering; Lignocellulose valorization; Metabolic engineering