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4266308 
Journal Article 
Review 
Metal-homeostasis in the pathobiology of the opportunistic human fungal pathogen Aspergillus fumigatus 
Blatzer, M; Latgé, JP 
2017 
Yes 
Current Opinion in Microbiology
ISSN: 1369-5274 
40 
152-159 
English 
29179120 
WOS:000418393000022 
In contrast to obligate pathogens opportunistic pathogens such as Aspergillus fumigatus do not need a specific host to propagate or survive. However several characteristics of the saprophytic life-style and the selective pressure encountered in the primary ecological niche contribute to the virulence of A. fumigatus. All fungi depend on metals for growth and proliferation, like iron, copper, zinc, manganese or calcium. In the recent past several studies explored the manifold impact of metals modulating virulence of pathogens. Components which might be scarce in the natural environment but also in the host due to nutritional immunity. This review recapitulates molecular constituents of metal ion uptake systems in A. fumigatus, their regulation and their significance at the host-pathogen battlefield.