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4270061 
Journal Article 
Abstract 
Effect of ontogenetic manganese exposure on dopaminergic system in 6-hydroxydopamine lesioned rats 
Szkilnik, R 
2011 
1 
Pharmacological Reports
ISSN: 1734-1140
EISSN: 2299-5684 
63 
2 
594 
English 
WOS:000291188700074 
The present study investigated the effect of neonatal manganese (Mn) exposure in a 6-hydroxydopamine (6-0HDA) rat model of Parkinson's disease. Pregnant Wistar rats were given drinking water with 10,000 ppm of manganese (MnCl(2).4H20) from the time of conception until weaning on the 21 st day after delivery. Control rats consumed tap water. Three days after birth, other groups of neonatal rat pups were pretreated with desipramine (20 mg/kg, ip 1 h) prior to bilateral icv administration of 6-0HDA (30, 60, or 137 Ilg) or its vehicle, saline-ascorbic (0.1 % ) (control). Two months after birth, striatal dopamine and homovanilic acid efflux was measured using microdialysis. Both 594 Pharmacological Reports, 2011, 63, 589-596 dopamine and homovanilic acid were reduced in rats lesioned with 30, 60, or 134 Ilg 6-0HDA. Co-exposure to perinatal Mn did not intensify neurotransmission disturbances; however, there were prominent abnormalities in behavioral testing (locomotor activity, exploratory activity, and irritability) in rats perinatally exposed to Mn and treated neonatally with 6-0HDA. These findings demonstrate that although Mn did not further damage neurotransmitter activity in the neo-striatum, ontogenetic exposure to Mn enhances the behavioral toxicity to 6-0HDA. 
manganese; ontogenetic; exposure; behavior; brain; microdialysis