rac-BINAP-PdCl2 catalyzed Heck reactions of 3-formylquinolin-2-yl chlorides with methyl acrylate: synthesis of methyl 3-(3-formylquinolin-2-yl) acrylates | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

4274495

Reference Type

Journal Article

Title

rac-BINAP-PdCl2 catalyzed Heck reactions of 3-formylquinolin-2-yl chlorides with methyl acrylate: synthesis of methyl 3-(3-formylquinolin-2-yl) acrylates

Author(s)

Sharma, N; Asthana, M; Kumar, R; Mishra, K; Singh, RM

Year

2014

Is Peer Reviewed?

Journal

Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581

Volume

Issue

Page Numbers

2348-2351

DOI

10.1016/j.tetlet.2014.02.081

Web of Science Id

WOS:000334977100005

URL

https://www.proquest.com/docview/2101378507?accountid=171501&bdid=64565&_bd=tCTUxSugYD7x9%2BM5B4s4E0BOI6g%3D
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Abstract

rac-BINAP-PdCl2 catalytic system catalyzed Heck reaction of 3-formylquinolin-2-yl chlorides with methyl acrylate in DMA is described to the synthesis of methyl 3-(3-formyl-quinolin-2-yl)-acrylates, in good to excellent yields. The reaction could be also extended with other activated alkenes to afford Heck products. Fused-benzene ring in heterocyclic and carbocyclic moieties was found to enhance the yields. (C) 2014 Elsevier Ltd. All rights reserved.

Keywords

Palladium; rac-BINAP; Heck reaction; Quinoline; Activated alkenes