[Bis-(trifluoroacetoxy)iodo]benzene-Mediated Oxidative Direct Amination C-N Bond Formation: Synthesis of 1H-Indazoles | Health & Environmental Research Online (HERO)

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HERO ID

4278156

Reference Type

Journal Article

Title

[Bis-(trifluoroacetoxy)iodo]benzene-Mediated Oxidative Direct Amination C-N Bond Formation: Synthesis of 1H-Indazoles

Author(s)

Zhang, Z; Huang, Y; Huang, G; Zhang, G; Liu, Q

Year

2017

Is Peer Reviewed?

Yes

Journal

Journal of Heterocyclic Chemistry
ISSN: 0022-152X

Volume

Issue

Page Numbers

2426-2433

Language

English

DOI

10.1002/jhet.2839

Web of Science Id

WOS:000405888800033

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024846918&doi=10.1002%2fjhet.2839&partnerID=40&md5=2b09b6c437bbc22085d069b4c884c081
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Abstract

An efficient [bis-(trifluoroacetoxy)iodo]benzene (PIFA)-mediated oxidative C-N bond formation is developed for the synthesis of 1H-indazoles from readily available arylhydrazones. The reaction tolerates a wide range of functional groups and has broad scope of substrates. Moreover, this method is a relative green and reliable method for rapid preparation of substituted 1H-indazoles under mild conditions.