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4279059 
Journal Article 
Measurement and Correlation of the Solubility of Telmisartan (Form A) in Nine Different Solvents from 277.85 to 338.35 K 
Liu, W; Guo, Y; Chen, J; Yu, Xi 
2016 
Yes 
Journal of Solution Chemistry
ISSN: 0095-9782
EISSN: 1572-8927 
45 
6 
932-946 
English 
WOS:000379492300009 
The solubility of telmisartan (form A) in nine organic solvents (chloroform, dichloromethane, ethanol, toluene, benzene, 2-propanol, ethyl acetate, methanol and acetone) was determined by a laser monitoring technique at temperatures from 277.85 to 338.35 K. The solubility of telmisartan (form A) in all of the nine solvents increased with temperature as did the rates at which the solubility increased except in chloroform and dichloromethane. The mole fraction solubility in chloroform is higher than that in dichloromethane, which are both one order of magnitude higher than those in the other seven solvents at the experimental temperatures. The solubility data were correlated with the modified Apelblat equation and lambda h equations. The results show that the lambda h equation is in better agreement with the experimental data than the Apelblat equation. The relative root mean square deviations (sigma) of the lambda h equation are in the range from 0.004 to 0.45 %. The dissolution enthalpies, entropies and Gibbs energies of telmisartan in these solvents were estimated by the Van't Hoff equation and the Gibbs equation. The melting point and the fusion enthalpy of telmisartan were determined by differential scanning calorimetry. 
Telmisartan; Solubility; Apelblat equation; lambda h equation; Solution thermodynamic properties