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4280912 
Journal Article 
POTENTIAL OF NATURAL ESSENTIAL OILS AND CINNAMALDEHYDE AS INSECTICIDES AGAINST THE DENGUE VECTOR AEDES AEGYPTI (DIPTERA: CULICIDAE) 
Chansang, A; Champakaew, D; Junkum, A; Amornlerdpison, D; Chaithong, U; Jitpakdi, A; Riyong, D; Wannasan, A; Intirach, J; Muangmoon, R; Pitasawat, B 
2018 
1 
Southeast Asian Journal of Tropical Medicine and Public Health
ISSN: 0125-1562 
49 
1 
6-22 
English 
WOS:000426140500002 
In order to search and develop a new and more efficacious natural alternative to synthetic chemicals for mosquito control, plants belonging to families known to possess insecticidal properties were selected for investigation of their lethal potential to adult stage. Essential oils isolated from eight indigenous plants using steam distillation were screened individually at a discriminating dosage (15 mu g/mg insect) for topical toxicity towards adult female Aedes aegypti, Mueang Chiang Mai-susceptible (MCM-S) strain. Dose-response bioassays of the effective oils indicated Cinnamomum verum bark oil, LD50 value of 3.37 mu g/mg female insect, as the most effective agent against MCM-S Ae. aegypti. Chemical analysis by gas chromatography-mass spectrometry revealed 16 different compounds, constituting 98.3% of C. verum oil composition, the most abundant being cinnamaldehyde (90.2%), followed by 2-propanyl benzene (4.2%) and 3-phenylpropanal (1.2%). LD50 value of C. verum oil and cinnamaldehyde against adult female MCM-S Ae. aegypti was 3.37 and 3.49 mu g/mg, respectively, and 3.27 and 3.73 mu g/mg, respectively, against adult female Pang Mai Dang-resistant (PMD-R) Ae. aegypti, over 1,000 folds less potent than of permethrin, with LD50 value of 0.43 and 3.72 ng/mg female against MCM-S and PMD-R strain, respectively. Although permethrin was more effective than C. verum oil (and cinnamaldehyde) against adult female Ae. aegypti, the former similar effectiveness against both MCM-S and PMD-R strains indicate the potential of developing C. verum oil and/or its main bioactive comstituents as natural alternative insecticides to synthetic chemical agents currently employed against adult female Ae. aegypti, a vector of dengue virus. 
Cinnamomum verum; Aedes aegypti; cinnamaldehyde; essential oil; insecticidal activity