Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
4284672
Reference Type
Journal Article
Title
SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME NOVEL 2,5-DIMETHYL PYRROLYL BENZOHYDRAZIDE DERIVATIVES
Author(s)
Dixit, SR; Joshi, SD; Kulkarni, VH; Panneerselvam, T
Year
2017
Is Peer Reviewed?
Yes
Journal
Indian Journal of Heterocyclic Chemistry
ISSN:
0971-1627
Volume
27
Issue
2
Page Numbers
117-121
Language
English
Web of Science Id
WOS:000410401200002
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097541592&partnerID=40&md5=e0392b7d96526d43d71f594a52fb3f49
Exit
Abstract
In an approach to combat the growing antitubercular resistance and to develop new antitubercular agents having more potent effect, here, we have synthesized some novel substituted 2,5-dimethylpyrrolyl benzohydrazide derivatives. 4-(2,5-Dimethyl-1H-pyrrol-1-yl) benzohydrazide (III), was synthesized using ethyl 4-aminobenzoate as starting material. The hydrazide III was reacted with substituted benzole acid using HBTU and DIEA in DMF to give 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N'-(substituted benzoyl) benzohydrazide derivatives IV(a-g). Structures of the newly synthesized compounds were confirmed on the basis of physicochemical parameters and spectral data (infrared, H-1 NMR, C-13 NMR, and mass spectra). All the synthesized compounds were screened for their antitubercular activity using Microplate Alamar Blue (R) Assay method. Compound IVf has showed better antitubercular activity at minimum inhibitory concentration value of 12.5 mu g/ml.
[GRAPHICS]
Keywords
Dimethyl pyrrole benzamide; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; N,N-Diisopropylethylamine; Antitubercular activity
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity