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4285162 
Journal Article 
Synthesis of Dichlorophosphinenickel(II) Compounds and Their Catalytic Activity in Suzuki Cross-Coupling Reactions: A Simple Air Free Experiment for Inorganic Chemistry Laboratory 
Thananatthanachon, T; Lecklider, MR 
2017 
Yes 
Journal of Chemical Education
ISSN: 0021-9584 
94 
6 
786-789 
English 
WOS:000404092400020 
In this experiment, students perform an air-free synthesis of three dichlorophosphinenickel(II) compounds, NiCl2(PPh3)(2), NiCl2(PCy3)(2), and NiCl2(DPPE), using NiCl2. 6H(2)O and the appropriate phosphine as the precursors. These colorful nickel compounds are air-sensitive in solution, but are stable toward air once isolated in the solid form. The synthesized nickel products will be utilized in a catalytic Suzuki cross-coupling reaction between phenylboronic acid and 1-bromo-4-(trifluoromethyl)benzene. The formation of the desired product, 4-(trifluoromethyl)biphenyl, is observed and determined quantitatively by F-19{H-1} NMR spectroscopy. The effect of the phosphine ligands on the formation of the nickel products and their catalytic activity will also be determined. KEYWORDS: Second-Year Undergraduate, Inorganic Chemistry, Hands-On Learning/Manipulatives, Laboratory Instruction, 
Second-Year Undergraduate; Inorganic Chemistry; Hands-On Learning/Manipulatives; Laboratory Instruction; Synthesis; Catalysis; Coordination Compounds; NMR Spectroscopy; UV Vis Spectroscopy