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4293772 
Journal Article 
Ibuprofen (motrin) hypersensitivity in intrinsic and extrinsic allergic patients 
Fisherman, EW; Cohen, GN 
1976 
Yes 
Annals of Allergy
ISSN: 0003-4738 
37 
5 
353-356 
English 
999055 
The introduction of new anti-inflammatory chemicals derived from propionic acid raised the possibility that they would not cross-react with the aspirin-salicylate type of anti-inflammatory drugs (and this group's cross-reactant chemicals). Thic allergic patients who have low tolerance for aspirin or BHA-BHT if concomitant low tolerance for iodides is also present. Likewise, ibuprofen is poorly tolerated by iodide intolerant patients. However, ASA or BHA-BHT intolerant patients who are tolerant of iodides tolerate a single 400 mgm motrin challenge; chronic motrin usage awaits further study. This study indicates that motrin is tolerated in patients tolerant of iodides but who suffer with extrinsic, atopic, allergic diseases and also in normals.