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HERO ID
4349516
Reference Type
Journal Article
Title
Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves
Author(s)
Sun, L; Zhang, J; Lu, X; Zhang, L; Zhang, Y
Year
2011
Is Peer Reviewed?
Yes
Journal
Food and Chemical Toxicology
ISSN:
0278-6915
EISSN:
1873-6351
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Volume
49
Issue
10
Page Numbers
2689-2696
Language
English
PMID
21802475
DOI
10.1016/j.fct.2011.07.042
Web of Science Id
WOS:000295241700029
Abstract
Persimmon leaves are commonly consumed as beverages, but are also used as a popular folk medicine in China. The purpose of this work is to assess the antioxidant activity of an extract of total flavonoids from persimmon leaves (TFPL). The effect of TFPL on total antioxidant activity, reducing power, 1,1-diphenyl-2-picrylhydrazyl (DPPH()) radical scavenging, superoxide anion (()O(2)(-)) radical scavenging, hydroxyl (OH()) radical scavenging and metal chelating activities was examined. We found that TFPL possesses considerable amounts of flavonoids (192μg catechin equivalent/g of extract). The effect of this extract in total antioxidant activity, scavenging activity of superoxide anion and hydroxyl radical, reducing power and iron chelating activity was significantly better than that of rutin. However, the effect of TFPL in free radical scavenging of DPPH() was significantly not as good as than rutin. In addition, TFPL significantly decreased the level of reactive oxygen species (ROS) and malondialdehyde (MDA), while increasing the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in MC3T3-E1 cells in a dose-dependent manner. In conclusion, TFPL possess potent antioxidant and free radical scavenging activities. These antioxidant activities could contribute, at least in part, to the traditionally claimed therapeutic benefits of persimmon leaves.
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