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4379178 
Journal Article 
Reagents for Bromination; Application in the Synthesis of Diterpenes, Sesquiterpenes and Bioactive Compounds 
Poon, PoS; Banerjee, AK; Vera, WJ; Bedoya, L 
2017 
Yes 
Current Organic Chemistry
ISSN: 1385-2728
EISSN: 1875-5348 
21 
10 
889-907 
Several organic compounds especially cyclic compounds containing double or triple bond and carbonyl compounds, aromatic compounds were brominated by employing several well-known reagents e.g., N-bromosuccinimide, bromine in acetic acid, ammonium bromide, hydrogen peroxide in acetic acid, carbon tetrabromide, phosphorous tribromide, 2,4,4,6-tetrabromocyclohex-2,5-dienone. The resulting compounds were utilized for the synthesis of several sesquiterpenes e.g., eudes-4(14)7(11)-diene-8-one, glutinosone, platyphyllide, occidentalol, drim-8-ene-7-one, cacalol, elemol, bakkenolide A, 10-bromo-alpha-chamigrene, allolaurintero, aplysin, costunolide, humulene, bisabollenes, bicycloelemene, occidol, longifolin, juvabiols, futronolide, etc. The importance of some of the mentioned reagents for bromination was also observed during the synthesis of the plant hormone abscisic acid, marine terpene synderol and alpha-asarone, a substance of potent hypolipidemic activity. The compounds obtained by bromination were likewise utilized for the synthesis of diterpenes like taxodione, spat-13,17-dien-5-ol and gibberellin A(12). Some of these bromo compounds were utilized for the synthesis of many substituted tetralones, tetralins and naphthalenes e.g., 6,7-dimethoxy-2-tetralone, 8-methyl-7-methoxy-1-tetralone, 8-methyl-1-tetralone, 1,4-dimethoxy-1-acetylnaphthalene, 7-methoxy-1-naphthylacetic acid, 5,6-dimethoxy1,2,3,4-tetrahydronaphthalene-2-carboxylic acid, 2-hydroxy-1,4-dimethoxynaphthalene which were utilized for the synthesis of many bioactive compounds. 
N-bromosuccinimide (NBS); bromine in acetic acid; carbon tetrabromide; ammoniun bromide; hydrogen peroxide; phosphorous tribromide; silver tetrafluoroborate; bromine