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HERO ID
4397324
Reference Type
Journal Article
Subtype
Review
Title
Dendrimers: novel polymeric nanoarchitectures for solubility enhancement
Author(s)
Gupta, U; Agashe, HB; Asthana, A; Jain, NK
Year
2006
Is Peer Reviewed?
Yes
Journal
Biomacromolecules
ISSN:
1525-7797
Publisher
AMER CHEMICAL SOC
Location
WASHINGTON
Volume
7
Issue
3
Page Numbers
649-658
Language
English
PMID
16529394
DOI
10.1021/bm050802s
Web of Science Id
WOS:000236136400001
Abstract
Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug delivery and formulation development. Apart from conventional methods of solubility enhancement, there are some novel methods which can be used in solubilization. Dendrimers represent a novel type of polymeric material that has generated much interest in many diverse areas due to their unique structure and properties. Dendrimer-mediated solubility enhancement mainly depends on factors such as generation size, dendrimer concentration, pH, core, temperature, and terminal functionality. Added advantage in solubilization can be achieved considering these factors. Available literature suggests that ionic interaction, hydrogen bonding, and hydrophobic interactions are the possible mechanisms by which a dendrimer exerts its solubilizing property. This review presents various mechanisms and reports relating to solubility enhancement using dendrimers. Also, micellar behavior and future possibilities in relation to solubilization via dendrimers are included.
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