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4411547 
Journal Article 
One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone 
Song, Lei; Zheng, M; Pang, J; Sebastian, J; Wang, W; Qu, M; Zhao, J; Wang, X; Zhang, Tao 
2017 
Yes 
Green Chemistry
ISSN: 1463-9262
EISSN: 1463-9270 
19 
15 
3515-3519 
WOS:000406615800005 
An efficient and green method for the synthesis of 2-hydroxymethyl-5-methylpyrazine was achieved from biomass derived 1,3-dihydroxyacetone and diammonium phosphate via a one-pot reaction. The product yield was as high as 72% under optimized conditions of pH = 8.0-9.1 at 90 degrees C for 1 hour in a dioxane and water mixture as a solvent. A possible reaction mechanism was proposed according to the reaction kinetics, NMR and in situ ATR-IR characterization studies. 
biomass; diammonium phosphate; dioxane; green chemistry; nuclear magnetic resonance spectroscopy; pyrazines; reaction kinetics; reaction mechanisms; solvents; synthesis