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4566359 
Journal Article 
Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application 
Prabhakar, N; Näreoja, T; von Haartman, E; Karaman, DŞ; Jiang, H; Koho, S; Dolenko, TA; Hänninen, PE; Vlasov, DI; Ralchenko, VG; Hosomi, S; Vlasov, II; Sahlgren, C; Rosenholm, JM 
2013 
1 
Nanoscale
ISSN: 2040-3364
EISSN: 2040-3372 
5 
9 
3713-3722 
English 
23493921 
Recent advances within materials science and its interdisciplinary applications in biomedicine have emphasized the potential of using a single multifunctional composite material for concurrent drug delivery and biomedical imaging. Here we present a novel composite material consisting of a photoluminescent nanodiamond (ND) core with a porous silica (SiO2) shell. This novel multifunctional probe serves as an alternative nanomaterial to address the existing problems with delivery and subsequent tracing of the particles. Whereas the unique optical properties of ND allows for long-term live cell imaging and tracking of cellular processes, mesoporous silica nanoparticles (MSNs) have proven to be efficient drug carriers. The advantages of both ND and MSNs were hereby integrated in the new composite material, ND@MSN. The optical properties provided by the ND core rendered the nanocomposite suitable for microscopy imaging in fluorescence and reflectance mode, as well as super-resolution microscopy as a STED label; whereas the porous silica coating provided efficient intracellular delivery capacity, especially in surface-functionalized form. This study serves as a demonstration how this novel nanomaterial can be exploited for both bioimaging and drug delivery for future theranostic applications.