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4567278 
Journal Article 
Glucose triggered enhanced solubilisation, release and cytotoxicity of poorly water soluble anti-cancer drugs fromT1307 micelles 
Patidar, P; Pillai, SA; Sheth, U; Bahadur, P; Bahadur, A 
2017 
Yes 
Journal of Biotechnology
ISSN: 0168-1656
EISSN: 1873-4863 
254 
43-50 
English 
28624378 
WOS:000405154500006 
Tetronic® 1307 (here after written as T1307) is a hydrophilic ethylene oxide-propylene oxide (EO-PO) star block copolymer with long EO chains (Total MW- 18000 and 70% EO). Although biocompatible, its use as a nanocarrier is restricted owing to its high critical micelle concentration (CMC) and temperature (CMT). We examined if the addition of glucose, a common pharmaceutical ingredient promotes micellization. Scattering and thermal studies show formation of stable unimodal micelles and cloud point (CP) decreased linearly. The solubilization of anticancer drugs viz. curcumin (CN) and quercetin (QN) demonstrates improved controlled release kinetics and cytotoxicity. On the whole, modulation in micellar behaviour by glucose opens enchanting possibility of using T1307 micelles as nanoreservoirs. 
Tetronics; Micelle; Cytotoxicity; Anticancer drugs; Solubilisation