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4579868 
Journal Article 
An efficient catalytic three-step synthesis of enantiopure triacylglycerols 
Fodran, P; Das, NJLC; Eisink, NNHM; Welleman, IM; Kloek, W; Minnaard, AJ 
2016 
1 
European Journal of Lipid Science and Technology
ISSN: 1438-7697
EISSN: 1438-9312 
118 
11 
1768-1774 
WOS:000387397700014 
With the developments in high performance chromatography and mass spectrometry, the analysis of complex mixtures of closely related triacylglycerols has come within reach. Currently, however, the availability of chemically pure triacylglycerols is limited, mainly due to the lack of efficient synthetic methods that allow their synthesis. Here, we report an efficient and operationally simple three-step synthesis of enantiopure triacylglycerols with yields ranging from 79 to 92%, that tolerates a broad range of saturated and unsaturated fatty acids. Furthermore, we developed an automated protocol, which might greatly facilitate the synthesis of triacylglycerol libraries. Practical applications: The analysis of the composition of milk fat and as analytical standards in lipidomics. 
Catalysis; Epoxide ringopening; Library synthesis; Milk fat; Triacylglycerols