Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
463477
Reference Type
Journal Article
Title
Asymptomatic rickets in adolescent girls
Author(s)
Dahifar, H; Faraji, A; Yassobi, S; Ghorbani, A
Year
2007
Is Peer Reviewed?
Yes
Journal
Indian Journal of Pediatrics
ISSN:
0019-5456
EISSN:
0973-7693
Volume
74
Issue
6
Page Numbers
571-575
Language
English
PMID
17595501
DOI
10.1007/s12098-007-0095-x
Abstract
Objective. Inadequate sunlight exposure and calcium intake during rapid growth at puberty lead to hypocalcemia, hypovitaminosis D and eventually to overt rickets. To determine serum biochemical findings of rickets in healthy 11-15 yr old girls, the effect of sunlight exposure and oral vitamin D supplementation on serum 25- hydroxy vitamin D and calcium administration in girls with abnormal findings during December 2002 through March 2003 in Tehran, Iran. Methods. Healthy middle school girls were selected for estimation of vitamin D, calcium and phosphorus intake by a three-day food recall. And measurment of serum calcium, phosphorus, parathyroid hormone, alkaline-phosphatase and 25- hydroxyvitamin D concentration. The girls with abnormal findings divided in two groups. Hypovitaminosis D girls subdivided into two groups, supplementary sunlight exposure and vitamin-D administrated for them and calcium administration for the second group for 20 days. Results. Of 414 girls, the mean daily vitamin D acquirment and calcium intake were 119 +/- 52 IU and 360 +/- 350 mg among all girls respectively. Mean serum 25-hydroxyvitamin D with two or more abnormal biochemical findings in 15 (3.6%) girls (group I) were 7.8 ng/ml and alkaline phosphatse with normal or low calcium in 29 (7%) girls ( group II) was 1187 IU/L. Mean serum calcium was 8.2 mg % in 8 of 29 girls. Serum 25- hydroxyvitamin D before and after sunlight exposure was 7.1 +/- 1.9 ng/ml and 13.9 +/- 2.4 ng/ml and vitamin D administration was 7.4 +/- 1.8 ng/ml (group Ia) and 27.9 +/- 4.2ng/ml (group Ib) respectively. Serum alkaline phosphatase before and after calcium administration were 1187 IU/L and 666 IU/L respectively. Conclusion. We conclude that low daily calcium intake, and vitamin D acquirment are two important problems in Iranian girls during rapid growth at puberty; therefore, for prevention of overt rickets calcium and vitamin D Supplementation appear to be necessary.
Keywords
hypovitaminosis; hypocalcemia; rickets; 25-hydroxyvitamin D; vitamin-d; deficiency; children; calcium; iron
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity