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463880 
Journal Article 
Cutaneous concentration of lycopene correlates significantly with the roughness of the skin 
Darvin, M; Patzelt, A; Gehse, S; Schanzer, S; Benderoth, C; Sterry, W; Lademann, J 
2008 
1 
European Journal of Pharmaceutics and Biopharmaceutics
ISSN: 0939-6411
EISSN: 1873-3441 
69 
3 
943-947 
English 
18411044 
Antioxidant substances in the skin are expected to slow down photo ageing. We therefore developed the hypothesis that high levels of antioxidant substances may be correlated to lower levels of skin roughness. By utilizing modern optical non-invasive in vivo methods, the structures of the furrows and wrinkles as well as the concentration of lycopene were analyzed quantitatively oil the forehead skin of 20 Volunteers aged between 40 and 50 years. In it first step, the age of the Volunteers was correlated to their skin roughness. Here, no significant correlation was found. In a second step, a significant correlation was obtained between the skin roughness and the lycopene concentration (R = 0.843). These findings indicate that higher levels of antioxidants in the skin effectively lead to lower levels of skin roughness, and therefore support Our hypothesis. (C) 2008 Elsevier B.V. All rights reserved. 
roughness; furrows; wrinkles; lycopene; free radicals; skin ageing; resonance raman-spectroscopy; in-vivo determination; beta-carotene; uv-light; ultraviolet; irradiation; delivery