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HERO ID
4642182
Reference Type
Journal Article
Title
Derivation of a No-Significant-Risk-Level (NSRL) for diethanolamine (DEA)
Author(s)
Wang, B; Amacher, DE; Whittaker, MH
Year
2014
Is Peer Reviewed?
1
Journal
Regulatory Toxicology and Pharmacology
ISSN:
0273-2300
EISSN:
1096-0295
Volume
68
Issue
1
Page Numbers
76-84
Language
English
PMID
24275050
DOI
10.1016/j.yrtph.2013.11.009
Web of Science Id
WOS:000330601500009
Abstract
Diethanolamine (DEA) has been listed on the State of California's Proposition 65 List. This listing is based in part on tumors reported in a National Toxicology Program (NTP) 2-year dermal carcinogenicity study in mice which found clear evidence of carcinogenic activity in B6C3F₁ mice based on increased incidences of liver neoplasms in both sexes, and increased incidences of renal tubule neoplasms in males. Although considerable controversy exists on the relevance of the NTP study to humans, industries are obligated to comply with the Proposition 65 labeling requirement and drinking water discharge prohibition, unless they are able to demonstrate that DEA levels in their products are below a specific No Significant Risk Level (NSRL). The State of California has not published an NSRL for DEA. In this article, a NSRL of 5.6 μg/day and a life-stage-adjusted NSRL(adj) of 1.4 μg/day are derived from the NTP carcinogenicity study using a benchmark dose modeling method based on the incidence of hepatocellular carcinomas in female mice, in accordance with the guidelines of California EPA.
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Additional PFAS (formerly XAgency)
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