Palladium-catalyzed intermolecular aminofluorination of styrenes | Health & Environmental Research Online (HERO)

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HERO ID

4654032

Reference Type

Journal Article

Title

Palladium-catalyzed intermolecular aminofluorination of styrenes

Author(s)

Qiu, S; Xu, T; Zhou, J; Guo, Y; Liu, G

Year

2010

Is Peer Reviewed?

Yes

Journal

Journal of the American Chemical Society
ISSN: 0002-7863
EISSN: 1520-5126

Volume

132

Issue

Page Numbers

2856-2857

Language

English

PMID

20148557

DOI

10.1021/ja909716k

Web of Science Id

WOS:000275660500005

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-77950403280&doi=10.1021%2fja909716k&partnerID=40&md5=617814c721f79e242127f0b7296989f3
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Abstract

A novel palladium-catalyzed intermolecular aminofluorination of styrenes, with N-fluorobenzenesulfonimide (NFSI) functioning not only as a fluorinating reagent but also as an aminating reagent, has been developed. The reaction afforded vicinal fluoroamine products with very high regioselectivity. This transformation may involve fluoropalladation of styrene as a key step for C-F bond formation. The bidental nitrogen ligand is crucial to achieving the transformation successfully.