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4654834 
Journal Article 
Review 
RISUG: an intravasal injectable male contraceptive 
Lohiya, NK; Alam, I; Hussain, M; Khan, SR; Ansari, AS 
2014 
1 
Indian Journal of Medical Research
ISSN: 0971-5916 
Indian Council of Medical Research 
140 Suppl 
S63-S72 
English 
25673546 
WOS:000350108000012 
Over the last two decades RISUG has been drawing attention in the field of male contraception. It promises to sterile men for a period of up to 10-15 years. According to recent studies in animal models, it proves to be completely reversible. Practically, there are no better options available that can assure complete sterility and precise reversibility. Regardless of so much of information available, RISUG is still holding up for many reasons, firstly, the available information engender bewilderment such as what is this copolymer, how does it work and is reversal really possible? Secondly, advancement of this outstanding invention is drastically slow and thirdly, effects of long-term contraception with RISUG and reports on evaluation of anomalies (if any) in F 1 , F 2 progenies, are lacking. In this review the lacunae as well as advances in the development of RISUG in the light of published work and available resources are pointed out. Formulation of the RISUG, its mode of action and clinical trials have been addressed with particular emphasis. 
Clinical trials; male contraception; RISUG; reversal; sperm; styrene maleic anhydride