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4658983 
Journal Article 
Review 
The use of poly(styrene-block-isobutylene-block-styrene) as a microshunt to treat glaucoma 
Pinchuk, L; Riss, I; Batlle, JF; Kato, YP; Martin, JB; Arrieta, E; Palmberg, P; Parrish, RK; Weber, BA; Kwon, Y; Parel, JM 
2016 
OXFORD UNIV PRESS 
OXFORD 
3 
2 
137-142 
English 
27047682 
WOS:000387386500013 
The InnFocus MicroShunt® is a minimally invasive glaucoma drainage microtube used to shunt aqueous humor from the anterior chamber of the eye to a flap formed under the conjunctiva and Tenon's capsule. The safety and clinical performance of this device approaches that of trabeculectomy with mitomycin C, the current 'gold standard' treatment for advanced glaucoma. The invention of a new biomaterial called poly(styrene-block-isobutylene-block-styrene) or 'SIBS' is the enabling factor which led to the success of this product. SIBS is ultrastable with virtually no foreign body reaction in the body, which manifests as clinically insignificant inflammation and capsule formation in the eye. The lack of capsule formation enables unobstructed flow through the 70 µm lumen tube and the achievement of controlled low intraocular pressure, which is important for the management of glaucoma. This article summarizes the integration of SIBS into a glaucoma drainage device and confirms its functionality with clinical success over a 2-year period. 
Biocompatibility; Medical device; Soft tissue; Stent