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4667930 
Journal Article 
Synthesis of Novel gamma-Ketoesters from Succinic Anhydride 
Iqbal, M; Baloch, IB; Baloch, MK 
2013 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
25 
17 
9701-9703 
English 
WOS:000330238700060 
Four alkyl gamma-ketohexanoates (3a-3d) have been prepared from succinic anhydride employing a three step reaction strategy. In the first step using p-toluene sulfonic acid as catalyst, the ring of succinic anhydride was opened with isopropyl, isobutyl, isopentyl and benzyl alcohols, respectively to form alkyl hydrogen succinates (1a-1d). In the 2nd step these alkyl hydrogen succinates on treatment with SOCl2 yielded 4-alkoxy-4-ketobutanoyl chlorides (2a-2d). The acid halides thus obtained, on reaction with diethyl cadmium led to require gamma-ketoesters. All the synthesised compounds were characterized by recording and analyzing H-1, C-13 NMR, IR spectra and mass measurements. 
gamma-Ketoesters; Isopentyl gamma-ketohexanoate; Succinic anhydride; Isobutyl alcohol