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4673035 
Journal Article 
Effects of experimental lead toxicity on hematology and biochemical parameters in Lohi sheep 
Sajid, M; Younus, M; Khan, M; Anjum, AA; Ehtisham-Ul-Haque, S 
2017 
Yes 
International Journal of Agriculture and Biology
EISSN: 1560-8530 
19 
6 
1409-1413 
English 
WOS:000416107100016 
The present study was conducted to investigate the hazardous effects of lead on blood, liver and kidney of Lohi sheep. The adult Lohi sheep (n=48) were divided into treatment and control groups. The treatment group was administered lead acetate at dose of 70 mg/kg live body weight daily for a period of 90 days orally. Six sheep from both groups were randomly selected and necropsied at day 0, 30, 60 and 90. The serum and tissue samples were collected and analyzed for Pb concentration by atomic absorption sepectrophotometry. The lead has significantly decreased the values of RBC, Hb and PCV; whereas ALT, AST, ALP, urea and creatinine levels were found higher in treatment group. It is concluded that, the tissue damage in Lohi sheep was dependant on accumulation of Pb residues in liver and kidney. This indicates that the lead intoxication could be harmful for sheep and ultimately poses threat for public health. This is first long term experimental study which correlates the effects of chronic Pb toxicity on blood and edible tissues of Lohi sheep. (C) 2017 Friends Science Publishers 
Lohi sheep; Lead acetate; Hematology; Serum