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467874 
Journal Article 
A comparative study of standard vs. high definition colonoscopy for adenoma and hyperplastic polyp detection with optimized withdrawal technique 
East, JE; Stavrindis, M; Thomas-Gibson, S; Guenther, T; Tekkis, PP; Saunders, BP 
2008 
Yes 
Alimentary Pharmacology and Therapeutics
ISSN: 0269-2813 
28 
6 
768-776 
English 
Background Colonoscopy has a known miss rate for polyps and adenomas. High definition (HD) colonoscopes may allow detection of subtle mucosal change, potentially aiding detection of adenomas and hyperplastic polyps. Aim To compare detection rates between HD and standard definition (SD) colonoscopy. Methods Prospective, cohort study with optimized withdrawal technique (withdrawal time > 6 min, antispasmodic, position changes, re-examining flexures and folds). One hundred and thirty patients attending for routine colonoscopy were examined with either SD (n = 72) or HD (n = 58) colonoscopes. Results Groups were well matched. Sixty per cent of patients had at least one adenoma detected with SD vs. 71% with HD, P = 0.20, relative risk (benefit) 1.32 (95% CI 0.85-2.04). Eighty-eight adenomas (mean +/- standard deviation 1.2 +/- 1.4) were detected using SD vs. 93 (1.6 +/- 1.5) with HD, P = 0.12; however more nonflat, diminutive (< 6 mm) adenomas were detected with HD, P = 0.03. Twenty-three proximal hyperplastic polyps (0.32 +/- 0.58) were detected with SD vs. 31 (0.53 +/- 0.86) with HD, P = 0.35. Overall prevalence of proximal large (> 9 mm) hyperplastic polyps was 7% (0.09 +/- 0.36). Conclusions High definition did not lead to a significant increase in adenoma or hyperplastic polyp detection, but may help where comprehensive lesion detection is paramount. High detection rates appear possible with either SD or HD, when using an optimized withdrawal technique. 
nonpolyposis colorectal-cancer; randomized controlled-trial; miss; rates; screening colonoscopy; serrated adenomas; position changes; natural-history; crossover trial; dye-spray; colon