Regioselective synthesis of 1-allyl- and 1-arylmethyl uracil and thymine derivatives | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4699378

Reference Type

Journal Article

Title

Regioselective synthesis of 1-allyl- and 1-arylmethyl uracil and thymine derivatives

Author(s)

Malik, V; Singh, P; Kumar, S

Year

2005

Is Peer Reviewed?

Journal

Tetrahedron
ISSN: 0040-4020

Volume

Issue

Page Numbers

4009-4014

DOI

10.1016/j.tet.2005.02.047

Web of Science Id

WOS:000228319200011

URL

http://www.sciencedirect.com/science/article/pii/S0040402005003340
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Abstract

2,4-Bis(trimethylsiloxy) pyrimidines 1 with allyl halides and arylmethyl halides in 1,2-dichloroethane in the presence of I-2 regioselectively provide 1-allyl-/1-arylmethyl-uracil and thymine derivatives. The secondary aryl alkyl and diaryl methyl halides with 1 provide chiral 1-arylalkyl/1-(diarylmethyl) uracil/thymine derivatives. The procedure has been extended to the synthesis of fluorescent uracil/thymine derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

Keywords

regioselective; allylation; arylmethyl; uracil and thymine