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4710559 
Journal Article 
Understanding How Nanopatterning Affects Protein Deposition 
Casey, BJ; Silverstein, JS; Kofinas, P; Dair, BJ 
2012 
CRC PRESS-TAYLOR & FRANCIS GROUP 
BOCA RATON 
Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 
683-685 
English 
WOS:000391247800180 
A photochemical, thiol-ene based modification scheme was utilized to functionalize block copolymers (BCPs) from the parent polymer poly(styrene)-block-poly(1,2-butadiene) (PS/PB). The films were then processed using suitable solvent systems, spin-coated, and dried which resulted in the development of functionalized, nanopatterned films. Protein (fibrinogen, albumin, cytochrome C, IgG) deposition experiments were conducted in both static and dynamic conditions utilizing a Q-Sense E4 Auto quartz crystal microbalance with dissipation technology (QCM-D). Results indicate that the functional group, pattern, and experimental conditions (e.g. static or dynamic) all influence protein adsorption dynamics. The results have direct implications for the development of testing protocols to assess the safety and efficacy of medical devices consisting of surfaces that have been manipulated on the nanoscale. 
block copolymer; thiol-ene; nanopattern; poly(styrene)-block-poly(1,2-butadiene); protein adsorption 
Laudon, M; Romanowicz, B; 
978-1-4665-6274-5 
NSTI Nanotechnology Conference and Expo (Nanotech 2012) 
Santa Clara, CA