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HERO ID
4715082
Reference Type
Journal Article
Title
Epoxide Hydrolases and their Application in Organic Synthesis
Author(s)
Kotik, M; Archelas, A; Wohlgemuth, R
Year
2012
Is Peer Reviewed?
Yes
Journal
Current Organic Chemistry
ISSN:
1385-2728
EISSN:
1875-5348
Volume
16
Issue
4
Page Numbers
451-482
DOI
10.2174/138527212799499840
Web of Science Id
WOS:000302376400002
Abstract
The number of synthetic applications of epoxide hydrolases in organic chemistry has reached a remarkable level. This has been due to a tremendous amount of work dedicated to the discovery of novel epoxide hydrolases from various biological sources, understanding the structure and function of these widespread enzymes and last but not least, the stabilization of these biocatalysts by various means for production purposes.
Keywords
Oxiranes; Enantioselectivity; Enantioconvergence; Kinetic Resolution; Desymmetrization; Asymmetric Synthesis; Biotransformation; Biocatalysis; Vicinal Diol; Chiral Synthon; Building Block
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