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4717985 
Journal Article 
CONFORMATIONAL ANALYSIS OF ALTERNATING COPOLYMERS AND THEIR ASSOCIATION INTO NANOARCHITECTURES 
Chan, ASW; Groves, M; Malardier-Jugroot, C 
2009 
Technical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009 
2 
439-442 
English 
WOS:000273330500117 
Our research focuses on the characterization of the association and the properties in aqueous solution of nanostructures, particularly on nanotubes composed of amphiphilic alternating copolymers. These copolymers constitute a pH sensitive hydrophilic group (maleic anhydride) alternating with a hydrophobic group. To investigate the role of the nature of the hydrophobic groups on the association, the self-assembly of two different polymers are compared: poly(isobutylene-alt-maleic anhydride) (IMA) and poly(styrene-alt-maleic anhydride) (SMA). It has been well reported that, at pH7, SMA forms stable nanotubes by association through a linear conformation due to H-bonding and pi-cation interactions. A theoretical approach was chosen to investigate and characterize the behavior of IMA chains at different pH values. To optimize IMA at different pH values, a complete conformational method was applied using both semi-empirical and ab initio molecular modeling methods. The present paper will describe in detail the conformational analysis of IMA, the association among IMA chains to form nanotubes and discuss the influence of the nature of the hydrophobic group on the association. The theoretical prediction will also be compared to experiment (dynamic light scattering) 
amphiphilic; copolymer; computational; characterization; IMA