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4721337 
Journal Article 
Proline/CuI Catalyzed Heck Reaction in Aqueous Two-Phase System 
Guo Shengrong; Yung Yanqin; Wang Yan; Zheng Yunfa 
2010 
1 
Youji Huaxue / Chinese Journal of Organic Chemistry
ISSN: 0253-2786 
30 
1 
60-65 
WOS:000274708600006 
The copper-catalyzed Heck reaction of acrylic ester or styrene with aryl halide gave the coupling products in good to excellent yields in aqueous two-phases system in 75 similar to 85 degrees C by using L-proline as a ligand. This method provides a new simple and inexpensive access to the Heck reaction. The structures of the products were confirmed by using spectroscopic techniques such as IR, H-1 NMR, C-13 NMR and comparing their melting points with known literature. 
aqueous two-phase system; Heck reaction; aryl halide; L-proline; CuI